Wick Husten-Sirup may be available in the countries listed below.
Dextromethorphan hydrobromide (a derivative of Dextromethorphan) is reported as an ingredient of Wick Husten-Sirup in the following countries:
International Drug Name Search
Wiatrim may be available in the countries listed below.
Sulfamethoxazole is reported as an ingredient of Wiatrim in the following countries:
Trimethoprim is reported as an ingredient of Wiatrim in the following countries:
International Drug Name Search
Dopamine hydrochloride (a derivative of Dopamine) is reported as an ingredient of Dopamine Hydrochloride in Dextrose in the following countries:
International Drug Name Search
Generic Name: citric acid and sodium citrate (SIT rik AS id and SOE dee um SIT rayt)
Brand Names: Bicitra, Cytra-2, Liqui-Dual Citra, Oracit
Citric acid and sodium citrate are both alkalinizing agents that make the urine less acidic.
The combination of citric acid and sodium citrate is used to prevent gout or kidney stones, or metabolic acidosis in people with kidney problems.
Citric acid and sodium citrate may also be used for other purposes not listed in this medication guide.
Before you take citric acid and sodium citrate, tell your doctor about all your medical conditions, especially kidney disease, heart disease, high blood pressure, a history of heart attack, urinary problems, swelling (edema), or chronic diarrhea (such as ulcerative colitis, Crohn's disease).
Also tell your doctor about all other medications you use, including over-the-counter medications and household remedies.
Citric acid and sodium citrate should be taken after meals to help prevent stomach or intestinal side effects.
Avoid using antacids without your doctor's advice, including household baking soda (sodium bicarbonate). Antacids that contain aluminum or sodium can interact with citric acid and sodium citrate, causing a serious electrolyte imbalance or aluminum toxicity.
Avoid eating foods that are high in salt, or using extra table salt on your meals.
To be sure citric acid and sodium citrate is helping your condition, your blood and urine may need to be tested often. Follow your doctor's instructions carefully and do not miss any scheduled appointments.
Serious side effects of citric acid and sodium citrate include muscle twitching or cramps, swelling or weight gain, weakness, mood changes, rapid and shallow breathing, fast heart rate, restless feeling, black or bloody stools, severe diarrhea, or seizure (convulsions).
kidney failure;
severe heart damage (such as from a prior heart attack);
Addison's disease (an adrenal gland disorder);
high levels of potassium in your blood (hyperkalemia); or
if you are severely dehydrated or have heat cramps.
If you have certain conditions, you may need a dose adjustment or special tests to safely take this medication. Before you take citric acid and sodium citrate, tell your doctor if you have:
congestive heart failure, enlarged heart, or history of heart attack;
other heart disease or high blood pressure;
low levels of calcium in your blood (hypocalcemia);
a urinary tract infection;
toxemia of pregnancy;
urination problems (or if you are unable to urinate);
swelling of your hands or feet, or in your lungs (pulmonary edema); or
chronic diarrhea (such as ulcerative colitis, Crohn's disease).
Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.
Citric acid and sodium citrate should be taken after meals to help prevent stomach or intestinal side effects. You may also need to take the medicine at bedtime. Follow your doctor's instructions.
Drink plenty of liquids while you are taking citric acid and sodium citrate.
To be sure citric acid and sodium citrate is helping your condition, your blood and urine may need to be tested often. Follow your doctor's instructions carefully and do not miss any scheduled appointments.
Take the missed dose as soon as you remember. If you are more than 2 hours late in taking your medicine, wait until your next regularly scheduled time to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.
Overdose symptoms may include muscle spasms or seizure (convulsions).
Avoid using antacids without your doctor's advice, including household baking soda (sodium bicarbonate). Antacids that contain aluminum or sodium can interact with citric acid and sodium citrate, causing a serious electrolyte imbalance or aluminum toxicity.
Avoid eating foods that are high in salt, or using extra table salt on your meals.
It is very important to follow any diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you should eat or avoid to help control your condition.
swelling, tingling, or numbness in your hands or feet;
muscle twitching or pain, leg pain or cramps;
unusual weakness, rapid and shallow breathing, fast or slow heart rate, dizziness, confusion, or mood changes;
feeling restless, nervous, or irritable;
black, bloody, or tarry stools;
severe or ongoing diarrhea; or
seizure (convulsions).
Less serious side effects may include:
nausea, or vomiting, stomach pain;
mild or occasional diarrhea; or
mild stomach pain.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
The following drugs can interact with citric acid and sodium citrate. Tell your doctor if you are using any of these:
lithium (Eskalith, LithoBid);
methenamine (Hiprex, Mandelamine, Urex),
quinidine (Quinaglute, Quinidex, Quin-Release);
cold or allergy medicine (decongestants), diet pills, ADHD medication;
a vitamin, mineral supplement, or medication that contains calcium;
salicylates such as aspirin, Backache Relief Extra Strength, Novasal, Nuprin Backache Caplet, Doan's Pills Extra Strength, Tricosal, and others; or
an antacid that contains aluminum or sodium, including Alka-Seltzer, Maalox, Mylanta, Di-Gel, Gelusil, Alamag Plus, Rulox Plus, Tempo, and others.
This list is not complete and there may be other drugs that can interact with citric acid and sodium citrate. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.
See also: Oracit side effects (in more detail)
Denagard®
(tiamulin)
Liquid Concentrate
12.3% Tiamulin hydrogen fumarate
NADA 140-916, Approved by FDA
One Quart
(32fl oz; 946mL)
Keep out of reach of children. Avoid direct contact with the skin. Direct contact with skin or mucous membranes may cause irritation.
Withdraw medicated water 3 days before slaughter after use at 3.5 mg per pound and 7 days before slaughter after use at 10.5 mg per pound.
This bottle contains 4.10 oz (116.4 g) tiamulin hydrogen fumarate in solution.
For use in animals only – Not for human use.
Prepare fresh medicated water daily. Use as the only source of drinking water for 5 days. The effects of tiamulin on swine reproductive performance, pregnancy and lactation have not been determined.
Swine being treated with Denagard (tiamulin) should not have access to feeds containing polyether ionophores (e.g., monensin, lasalocid, narasin, salinomycin and semduramicin) as adverse reactions may occur.
Treatment of swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae and swine pneumonia due to Actinobacillus pleuropneumoniae, susceptible to tiamulin.
Do not use undiluted.
This bottle contains 116,400 mg tiamulin hydrogen fumarate for use in preparing medicated drinking water for swine. See package insert for complete directions, read completely.
Protect from direct sunlight. Store at controlled room temperature, 59°-86°F (15°-30°C).
Restricted Drug (California): Use only as directed
Denagard® is a registered trademark of Novartis AG
U.S. Patent No. 4,278,674
Product # 701
NAH/DEN-LC/BL/2
Marketed by:
Novartis Animal Health US, Inc.
Greensboro, NC 27408 U.S.A.
NADA 140-916, Approved by FDA
Denagard®
(tiamulin)
Liquid Concentrate
Denagard (tiamulin) Liquid Concentrate is a solution containing 12.3% tiamulin hydrogen fumarate (w/v) in an aqueous solution. The active ingredient, tiamulin, chemically is 14-desoxy-14-[(2-diethylaminoethyl) mercaptoacetoxy] mutilin hydrogen fumarate, a semi-synthetic diterpene antibiotic. Denagard Liquid Concentrate is for use only in preparing medicated drinking water for swine.
Tiamulin is active against Brachyspira (formerly Serpulina or Treponema) hyodysenteriae and Actinobacillus pleuropneumoniae. It is readily absorbed from the gut and can be found in the blood within 30 minutes after dosing.
Denagard (tiamulin), when administered in the drinking water for five consecutive days, is an effective antibiotic for the treatment of swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae susceptible to tiamulin at a dose level of 3.5 mg tiamulin hydrogen fumarate per pound of body weight daily and for treatment of swine pneumonia due to Actinobacillus pleuropneumoniae susceptible to tiamulin when given at 10.5 mg tiamulin hydrogen fumarate per pound of body weight daily.
Swine being treated with Denagard (tiamulin) should not have access to feeds containing polyether ionophores (e.g., monensin, lasalocid, narasin, salinomycin and semduramicin) as adverse reactions may occur.
Keep out of reach of children. Avoid contact with skin. Direct contact with skin or mucous membranes may cause irritation.
Withdraw medicated water 3 days before slaughter after treatment at 3.5 mg per pound and 7 days before slaughter following treatment at 10.5 mg per pound body weight.
For use in drinking water of swine only. Prepare fresh medicated water daily. The effects of tiamulin on swine reproductive performance, pregnancy and lactation have not been determined. For animal use only – not for use in humans.
Overdoses of Denagard have sometimes produced transitory salivation, vomiting and an apparent calming effect on the pig. If signs of toxicity occur, discontinue use of medicated water and replace with clean, fresh water.
In rare cases, redness of the skin primarily over the ham and underline has been observed during medication. If these signs appear, discontinue use of this drug. Provide ample clean drinking water. Thoroughly rinse (hose down) the housing to remove urine and feces from animal contact surfaces or move the animals to clean pens. If the condition persists, consult your veterinarian.
Studies to evaluate the safety of the water soluble form of tiamulin in breeding swine have not been done.
The concentration of tiamulin in the drinking water must be adjusted to compensate for variation in water consumption due to weight or size of the pig, environmental temperature and other factors. It is important that pigs receive the proper drug dose, 3.5 mg tiamulin hydrogen fumarate per pound for swine dysentery or 10.5 mg tiamulin hydrogen fumarate per pound for swine pneumonia, each day for 5 consecutive days.
| Pig Weight, lb | Water Intake, gal. | Pig Weight, lb | Water Intake, gal. |
| 20 | 0.3 - 0.5 | 125 | 1.0 – 2.0 |
| 45 | 0.4 – 1.1 | 180 | 1.2 – 3.0 |
| 75 | 0.7 – 1.5 |
Note:
Directions for preparing Denagard medicated solutions: Determine the amount of Denagard Liquid Concentrate needed to medicate the desired volume of drinking water at the proper concentration. Carefully measure out this amount, add it to the water and stir to thoroughly mix.
| One Quart | ||||
| Net tiamulin hydrogen fumarate content: | 116,400 mg | |||
| Diseases to be treated: | Swine Dysentery | Swine Pneumonia | ||
| Daily tiamulin hydrogen fumarate required per pound body weight: | 3.5 mg | 10.5 mg | ||
| Required treatment duration: | 5 days | 5 days | ||
| Pig body weight this bottle will treat for ONE day: | 33,257 lb | 11,086 lb | ||
| Number of pigs this bottle will treat for ONE day: | Pig Wt, lb | |||
| 20 | 1,663 | 554 | ||
| 45 | 739 | 246 | ||
| 75 | 443 | 148 | ||
| 125 | 266 | 88 | ||
| 180 | 185 | 62 | ||
| Suggested final dilution of: | 1 bottle | 512 gal | - | |
| 3 bottles | - | 512 gal | ||
| ½ pint (8 oz) | 128 gal | 43 gal | ||
| 1½ pints (24 oz) | - | 128 gal | ||
| Tiamulin hydrogen fumarate concentration per gallon at suggested final dilution* | 227 mg (60 ppm) | 681 mg (180 ppm) | ||
*Note: Increase or decrease dilution rate as required to obtain proper daily drug dose.
Directions for using Denagard in medicated proportioners: One quart of Denagard Liquid Concentrate mixed with water to make four gallons of stock solution and this stock solution metered at one fluid ounce per gallon will provide 227 mg of tiamulin hydrogen fumarate per gallon to 512 gallons of drinking water for treatment of swine dysentery. Three quarts of Denagard Liquid Concentrate mixed with water to make four gallons of stock solution and this stock solution metered at one fluid ounce per gallon will provide 681 mg tiamulin hydrogen fumarate per gallon to a total of 512 gallons of drinking water for treatment of swine pneumonia.
One pint of Denagard Liquid Concentrate mixed with water to make two gallons of stock solution and this stock solution metered at one fluid ounce per gallon will provide 227 mg of tiamulin hydrogen fumarate per gallon to 256 gallons of drinking water for treatment of swine dysentery. Use three pints of Denagard Liquid Concentrate in two gallons of stock solution to be metered at one fluid ounce per gallon to deliver 681 mg per gallon to a total of 256 gallons of drinking water for treatment of swine pneumonia.
One-half pint (8 fluid ounces) of Denagard Liquid Concentrate diluted with water to make one gallon of stock solution and this stock solution metered at one fluid ounce of drinking water with a medication proportioner will provide 227 mg of tiamulin hydrogen fumarate per gallon to 128 gallons of drinking water for treatment of swine dysentery.
Use one and one-half pints of Denagard Liquid Concentrate per gallon of stock solution to be metered at one fluid ounce per gallon to provide 681 mg per gallon to 128 gallons of drinking water for treatment of swine pneumonia.
In barrels or tanks: Three fluid ounces of Denagard Liquid Concentrate will medicate 48 gallons of drinking water at 227 mg per gallon for treatment of swine dysentery or 16 gallons at 681 mg per gallon for treatment of swine pneumonia.
Measure Denagard Liquid concentrate carefully, pour into the proper amount of water and thoroughly mix. The concentration of tiamulin hydrogen fumarate in the stock solution and in the drinking water delivered must be adjusted to compensate for variation in water consumption by pigs due to body weight, environmental and other factors. It is important that the pigs receive the proper drug dose of 3.5 mg of tiamulin hydrogen fumarate per pound of body weight daily for 5 consecutive days for treatment of swine dysentery or a dose of 10.5 mg per pound body weight daily for 5 consecutive days for treatment of swine pneumonia.
Attention: If no response to treatment is obtained within 5 days re-establish the diagnosis. Failure of response may be related to the presence of non-susceptible organisms of other complicating disease conditions. Because of the tendency for the disease to recur on premises with a history of swine dysentery or with swine pneumonia, a control program should be implemented after treatment. Drugs are not substitutes for proper sanitary measures or good management, but should be used in conjunction with such practices.
| Container Size | Active Ingredients |
| Quart bottles | 12.3% (116.4g) |
| (32 fl oz; 946 mL) | Tiamulin hydrogen fumarate |
Protect from direct sunlight. Store at controlled room temperature, 59°-86°F (15°-30°C).
Observe expiration date.
U.S. Patent No. 4,278,674
Denagard®
(tiamulin)
Liquid Concentrate
12.3% Tiamulin
hydrogen fumarate
NADA 140-916,
Approved by FDA
One Quart
(32 fl oz; 946 mL)
NOVARTIS
ANIMAL HEALTH
| Denagard tiamulin solution, concentrate | ||||||||||||||||||||
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| Marketing Information | |||
| Marketing Category | Application Number or Monograph Citation | Marketing Start Date | Marketing End Date |
| NADA | NADA140916 | 01/29/1993 | |
| Labeler - Novartis Animal Health US, Inc. (966985624) |
Atarax-P may be available in the countries listed below.
Hydroxyzine embonate (a derivative of Hydroxyzine) is reported as an ingredient of Atarax-P in the following countries:
Hydroxyzine hydrochloride (a derivative of Hydroxyzine) is reported as an ingredient of Atarax-P in the following countries:
International Drug Name Search
Witgen may be available in the countries listed below.
Memantine hydrochloride (a derivative of Memantine) is reported as an ingredient of Witgen in the following countries:
International Drug Name Search
